Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein

The identification of the neutralization domains of hepatitis C virus (HCV) is essential for the development of an effective vaccine. Here, we show that the hypervariable region 1 (HVR1) of the envelope 2 (E2) protein is a critical neutralization domain of HCV. Neutralization of HCV in vitro was att...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Farci, Patrizia, Shimoda, Atsushi, Wong, Doris, Cabezon, Teresa, De Gioannis, Daniela, Strazzera, Antonello, Shimizu, Yohko, Shapiro, Max, Alter, Harvey J., Purcell, Robert H.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1996
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26415/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8986822/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.26.15394
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