Cbl Enforces an SLP76-dependent Signaling Pathway for T Cell Differentiation

A signaling pathway involving ZAP-70, LAT, and SLP76 has been regarded as essential for receptor-driven T cell development and activation. Consistent with this model, mice deficient in SLP76 have a complete block at the double negative 3 stage of T cell development. Recently, however, it has been re...

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Bibliographic Details
Main Authors: Chiang, Y. Jeffrey, Jordan, Martha S., Horai, Reiko, Schwartzberg, Pamela L., Koretzky, Gary A., Hodes, Richard J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640981/
https://ncbi.nlm.nih.gov/pubmed/19074136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808679200
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