NF-κB Transcription Factor p50 Critically Regulates Tissue Factor in Deep Vein Thrombosis

NF-κB transcription factors regulate the expression of tissue factor (TF), a principal initiator of the coagulation cascade. Dominant among them is the p50/p65 heterodimer. Here we report that Andrographolide (Andro; a p50 inhibitor) and genetic deletion of p50 attenuated TF activity in stimulated e...

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Detalles Bibliográficos
Main Authors: Li, Yi-Dan, Ye, Bu-Qing, Zheng, Sheng-Xi, Wang, Jin-Tao, Wang, Jian-Guo, Chen, Ming, Liu, Ji-Guo, Pei, Xin-Hui, Wang, Li-Jing, Lin, Zhi-Xin, Gupta, Kalpna, Mackman, Nigel, Slungaard, Arne, Key, Nigel S., Geng, Jian-Guo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Transcription, Chromatin, and Epigenetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640971/
https://ncbi.nlm.nih.gov/pubmed/19095643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806010200
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