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CD40-CD40 Ligand Interactions in Human Microglia Induce CXCL8 (Interleukin-8) Secretion by a Mechanism Dependent on Activation of ERK1/2 and Nuclear Translocation of Nuclear Factor-κB (NFκB) and Activator Protein-1 (AP-1)

CXCL8 is a CXC chemokine that recruits leukocytes to sites of inflammation. Expression of CXCL8 in the CNS has been demonstrated in neuroinflammatory diseases, including human immunodeficiency virus (HIV-1) encephalitis, but the mechanism of secretion of this chemokine is not fully understood. CD40...

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Hlavní autoři: D’Aversa, Teresa G., Eugenin, Eliseo A., Berman, Joan W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639790/
https://ncbi.nlm.nih.gov/pubmed/17918746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.21525
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