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How do SET-domain Protein Lysine Methyltransferases Achieve the Methylation State Specificity? Revisited by ab initio QM/MM Molecular Dynamics Simulations

A distinct protein lysine methyltransferase (PKMT) only transfers a certain number of methyl group(s) to its target lysine residue in spite of the fact that a lysine residue can be either mono-, di-, or tri-methylated. In order to elucidate how such a remarkable product specificity is achieved, we h...

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Detalhes bibliográficos
Main Authors: Hu, Po, Wang, Shenglong, Zhang, Yingkai
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639776/
https://ncbi.nlm.nih.gov/pubmed/18311969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja075896n
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