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How do SET-domain Protein Lysine Methyltransferases Achieve the Methylation State Specificity? Revisited by ab initio QM/MM Molecular Dynamics Simulations
A distinct protein lysine methyltransferase (PKMT) only transfers a certain number of methyl group(s) to its target lysine residue in spite of the fact that a lysine residue can be either mono-, di-, or tri-methylated. In order to elucidate how such a remarkable product specificity is achieved, we h...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2639776/ https://ncbi.nlm.nih.gov/pubmed/18311969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja075896n |
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