MMTV-Wnt1 and -ΔN89β-Catenin Induce Canonical Signaling in Distinct Progenitors and Differentially Activate Hedgehog Signaling within Mammary Tumors

Canonical Wnt/β-catenin signaling regulates stem/progenitor cells and, when perturbed, induces many human cancers. A significant proportion of human breast cancer is associated with loss of secreted Wnt antagonists and mice expressing MMTV-Wnt1 and MMTV-ΔN89β-catenin develop mammary adenocarcinomas....

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Bibliographic Details
Main Authors: Teissedre, Brigitte, Pinderhughes, Alicia, Incassati, Angela, Hatsell, Sarah J., Hiremath, Minoti, Cowin, Pamela
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639708/
https://ncbi.nlm.nih.gov/pubmed/19225568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004537
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