Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity

BACKGROUND: Cisplatin is a cornerstone anticancer drug with pronounced ototoxicity, whereas oxaliplatin, a platinum derivative with a different clinical profile, is rarely ototoxic. This difference has not been explained. METHODS: In HCT116 cells, cisplatin (20 μM)-induced apoptosis was reduced by a...

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Hauptverfasser: Hellberg, Victoria, Wallin, Inger, Eriksson, Sofi, Hernlund, Emma, Jerremalm, Elin, Berndtsson, Maria, Eksborg, Staffan, Arnér, Elias S. J., Shoshan, Maria, Ehrsson, Hans, Laurell, Göran
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2009
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639295/
https://ncbi.nlm.nih.gov/pubmed/19116379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djn418
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