Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON l-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease

OFF-l-dopa dyskinesias have been a surprising side-effect of intrastriatal foetal ventral mesencephalic transplantation in patients with Parkinson's disease. It has been proposed that excessive and unregulated dopaminergic stimulation of host post-synaptic striatal neurons by the grafts could b...

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Bibliographic Details
Main Authors: Vinuela, A., Hallett, P. J., Reske-Nielsen, C., Patterson, M., Sotnikova, T. D., Caron, M. G., Gainetdinov, R. R., Isacson, O.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639209/
https://ncbi.nlm.nih.gov/pubmed/18988638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awn192
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