Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity

Benzene is an established human hematotoxicant and leukemogen but its mechanism of action is unclear. To investigate the role of single-nucleotide polymorphisms (SNPs) on benzene-induced hematotoxicity, we analyzed 1395 SNPs in 411 genes using an Illumina GoldenGate assay in 250 benzene-exposed work...

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Detalhes bibliográficos
Main Authors: Lan, Qing, Zhang, Luoping, Shen, Min, Jo, William J., Vermeulen, Roel, Li, Guilan, Vulpe, Christopher, Lim, Sophia, Ren, Xuefeng, Rappaport, Stephen M., Berndt, Sonja I., Yeager, Meredith, Yuenger, Jeff, Hayes, Richard B., Linet, Martha, Yin, Songnian, Chanock, Stephen, Smith, Martyn T., Rothman, Nathaniel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Molecular Epidemiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639030/
https://ncbi.nlm.nih.gov/pubmed/18978339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgn249
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