FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway

Activating mutations in FGFR3 cause achondroplasia and thanatophoric dysplasia, the most common human skeletal dysplasias. In these disorders, spinal canal and foramen magnum stenosis can cause serious neurologic complications. Here, we provide evidence that FGFR3 and MAPK signaling in chondrocytes...

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Bibliografiset tiedot
Päätekijät: Matsushita, Takehiko, Wilcox, William R., Chan, Yuk Yu, Kawanami, Aya, Bükülmez, Hülya, Balmes, Gener, Krejci, Pavel, Mekikian, Pertchoui B., Otani, Kazuyuki, Yamaura, Isakichi, Warman, Matthew L., Givol, David, Murakami, Shunichi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2009
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638772/
https://ncbi.nlm.nih.gov/pubmed/18923003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn339
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