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FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway
Activating mutations in FGFR3 cause achondroplasia and thanatophoric dysplasia, the most common human skeletal dysplasias. In these disorders, spinal canal and foramen magnum stenosis can cause serious neurologic complications. Here, we provide evidence that FGFR3 and MAPK signaling in chondrocytes...
Αποθηκεύτηκε σε:
Κύριοι συγγραφείς: | , , , , , , , , , , , , |
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Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
Oxford University Press
2009
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2638772/ https://ncbi.nlm.nih.gov/pubmed/18923003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn339 |
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