Protein kinase C activation stabilizes LDL receptor mRNA via the JNK pathway in HepG2 cells

LDL is the most abundant cholesterol transport vehicle in plasma and a major prognostic indicator of atherosclerosis. Hepatic LDL receptors limit circulating LDL levels, since cholesterol internalized by the liver can be excreted. As such, mechanisms regulating LDL receptor expression in liver cells...

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Bibliographic Details
Main Authors: Vargas, Noelle B., Brewer, Brandy Y., Rogers, Terry B., Wilson, Gerald M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638102/
https://ncbi.nlm.nih.gov/pubmed/18936517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800316-JLR200
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