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Small molecule blockers of the Alzheimer Aβ calcium channel potently protect neurons from Aβ cytotoxicity

Alzheimer's disease (AD) is a common, chronic neurodegenerative disease that is thought to be caused by the neurotoxic effect of the Amyloid beta peptides (Aβ). We have hypothesized that the intrinsic Aβ calcium channel activity of the oligomeric Aβ polymer may be responsible for the neurotoxic...

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Bibliografiske detaljer
Main Authors: Diaz, Juan Carlos, Simakova, Olga, Jacobson, Kenneth A., Arispe, Nelson, Pollard, Harvey B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637905/
https://ncbi.nlm.nih.gov/pubmed/19204293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813355106
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