Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN)

OBJECTIVE: Chemokine receptors are G-protein coupled receptors (GPCRs) phosphorylated by G-protein receptor kinases (GRKs) after ligand-mediated activation. We hypothesized that GRK subtypes differentially regulate granulocyte chemotaxis and clinical disease expression in the K/BxN model. METHODS: C...

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Huvudupphovsmän: Terrant, Teresa K., Rampersad, Rishi R., Esserman, Denise, Rothlein, Lisa R., Liu, Peng, Premont, Richard T., Lefkowitz, Robert J., Lee, David M., Patel, Dhavalkumar D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637521/
https://ncbi.nlm.nih.gov/pubmed/18662895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2008.06.008
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