PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation

Ubiquilins (UBQLNs) are adaptor proteins thought to deliver ubiquitinated substrates to proteasomes. Here, we show a role for UBQLN in autophagy: enforced expression of UBQLN protects cells from starvation-induced death, whereas depletion of UBQLN renders cells more susceptible. The UBQLN protective...

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Bibliographic Details
Main Authors: N'Diaye, Elsa-Noah, Kajihara, Kimberly K, Hsieh, Ivy, Morisaki, Hiroshi, Debnath, Jayanta, Brown, Eric J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
Subjects:
Scientific Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637314/
https://ncbi.nlm.nih.gov/pubmed/19148225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.238
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