A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9

Greater understanding of metastasis is required to improve cancer treatment outcomes. Recently, changes in expression of the scaffold protein HEF1/CAS-L/NEDD9 were found to be a potent pro-metastatic stimulus in melanoma and other cancers. Mechanistic studies suggest diverse cellular roles of HEF1 a...

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Päätekijät: O’Neill, Geraldine M., Seo, Sachiko, Serebriiskii, Ilya G., Lessin, Stuart R., Golemis, Erica A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2007
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637184/
https://ncbi.nlm.nih.gov/pubmed/17908996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-1328
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spelling pubmed-26371842009-02-06 A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9 O’Neill, Geraldine M. Seo, Sachiko Serebriiskii, Ilya G. Lessin, Stuart R. Golemis, Erica A. Cancer Res Article Greater understanding of metastasis is required to improve cancer treatment outcomes. Recently, changes in expression of the scaffold protein HEF1/CAS-L/NEDD9 were found to be a potent pro-metastatic stimulus in melanoma and other cancers. Mechanistic studies suggest diverse cellular roles of HEF1 and highlight its importance in the response to extracellular cues that drive invasion and metastasis. As a metastatic “hub” for signaling in cancer, HEF1 may provide a useful target for drug discovery efforts. 2007-10-01 /pmc/articles/PMC2637184/ /pubmed/17908996 http://dx.doi.org/10.1158/0008-5472.CAN-07-1328 Text en
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Article
spellingShingle Article
O’Neill, Geraldine M.
Seo, Sachiko
Serebriiskii, Ilya G.
Lessin, Stuart R.
Golemis, Erica A.
A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
description Greater understanding of metastasis is required to improve cancer treatment outcomes. Recently, changes in expression of the scaffold protein HEF1/CAS-L/NEDD9 were found to be a potent pro-metastatic stimulus in melanoma and other cancers. Mechanistic studies suggest diverse cellular roles of HEF1 and highlight its importance in the response to extracellular cues that drive invasion and metastasis. As a metastatic “hub” for signaling in cancer, HEF1 may provide a useful target for drug discovery efforts.
author O’Neill, Geraldine M.
Seo, Sachiko
Serebriiskii, Ilya G.
Lessin, Stuart R.
Golemis, Erica A.
author_facet O’Neill, Geraldine M.
Seo, Sachiko
Serebriiskii, Ilya G.
Lessin, Stuart R.
Golemis, Erica A.
author_sort O’Neill, Geraldine M.
title A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
title_short A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
title_full A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
title_fullStr A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
title_full_unstemmed A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9
title_sort new central scaffold for metastasis: parsing hef1/cas-l/nedd9
publishDate 2007
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2637184/
https://ncbi.nlm.nih.gov/pubmed/17908996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-1328
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