Distinct Functions of Activated Protein C Differentially Attenuate Acute Kidney Injury

Administration of activated protein C (APC) protects from renal dysfunction, but the underlying mechanism is unknown. APC exerts both antithrombotic and cytoprotective properties, the latter via modulation of protease-activated receptor-1 (PAR-1) signaling. We generated APC variants to study the rel...

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Main Authors: Gupta, Akanksha, Gerlitz, Bruce, Richardson, Mark A., Bull, Christopher, Berg, David T., Syed, Samreen, Galbreath, Elizabeth J., Swanson, Barbara A., Jones, Bryan E., Grinnell, Brian W.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2009
Teme:
Basic Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637057/
https://ncbi.nlm.nih.gov/pubmed/19092124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008030294
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