Intermittent hypoxia activates peptidylglycine α-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing

Intermittent hypoxia (IH) associated with sleep apneas leads to cardiorespiratory abnormalities that may involve altered neuropeptide signaling. The effects of IH on neuropeptide synthesis have not been investigated. Peptidylglycine α-amidating monooxygenase (PAM; EC 1.14.17.3) catalyzes the α-amida...

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Main Authors: Sharma, Suresh D., Raghuraman, Gayatri, Lee, Myeong-Seon, Prabhakar, Nanduri R., Kumar, Ganesh K.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636940/
https://ncbi.nlm.nih.gov/pubmed/18818385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.90702.2008
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