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Stimulation of Sister Chromatid Exchanges and Mutation by Aflatoxin B(1)-DNA Adducts in Saccharomyces cerevisiae Requires MEC1 (ATR), RAD53, and DUN1
The hepatocarcinogen aflatoxin B(1) (AFB(1)) is a potent recombinagen but weak mutagen in the yeast Saccharomyces cerevisiae. AFB(1) exposure induces DNA damage-inducible genes, such as RAD51 and those encoding ribonucleotide reductase (RNR), through a MEC1 (ATR homolog)-dependent pathway. Previous...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2636728/ https://ncbi.nlm.nih.gov/pubmed/18228255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20417 |
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