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CD4 deficits and Disease Course Acceleration can be driven by a collapse of the CD8 response in SIV-infected Rhesus Macaques

OBJECTIVES: Defects in memory CD4+ T cells correlate with development of AIDS in SIV-infected monkeys, but the early events leading to these deficits are unknown. We explored the role of SIV-specific and CD8 cells in the determination of CD4 failure and rapid disease course. DESIGN AND METHODS: Usin...

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Bibliografiset tiedot
Päätekijät: Marcondes, Maria Cecilia G., Sopper, Sieghart, Sauermann, Ulrike, Burdo, Tricia H., Watry, Debbie, Zandonatti, Michelle, Fox, Howard S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636707/
https://ncbi.nlm.nih.gov/pubmed/18614867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3283052fb5
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