Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity

Myc activity is emerging as a key element in acquisition and maintenance of stem cell properties. We have previously shown that c-Myc deficiency results in accumulation of defective hematopoietic stem cells (HSCs) due to niche-dependent differentiation defects. Here we report that immature HSCs coex...

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Detalhes bibliográficos
Main Authors: Laurenti, Elisa, Varnum-Finney, Barbara, Wilson, Anne, Ferrero, Isabel, Blanco-Bose, William E., Ehninger, Armin, Knoepfler, Paul S., Cheng, Pei-Feng, MacDonald, H. Robson, Eisenman, Robert N., Bernstein, Irwin D., Trumpp, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635113/
https://ncbi.nlm.nih.gov/pubmed/19041778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.09.005
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