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Crystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid Lipofuscinosis

Late infantile neuronal ceroid lipofuscinosis is a fatal childhood neurological disorder caused by a deficiency in the lysosomal protease tripeptidyl-peptidase 1 (TPP1). TPP1 represents the only known mammalian member of the S53 family of serine proteases, a group characterized by a subtilisin-like...

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Main Authors: Guhaniyogi, Jayita, Sohar, Istvan, Das, Kalyan, Stock, Ann M., Lobel, Peter
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635056/
https://ncbi.nlm.nih.gov/pubmed/19038967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806943200
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