The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA

Mammalian DAI (DNA-dependent activator of IFN-regulatory factors), an activator of the innate immune response, senses cytosolic DNA by using 2 N-terminal Z-DNA binding domains (ZBDs) and a third putative DNA binding domain located next to the second ZBD. Compared with other previously known ZBDs, th...

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Detalles Bibliográficos
Main Authors: Ha, Sung Chul, Kim, Doyoun, Hwang, Hye-Yeon, Rich, Alexander, Kim, Yang-Gyun, Kim, Kyeong Kyu
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634953/
https://ncbi.nlm.nih.gov/pubmed/19095800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810463106
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