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Failure of T cell homing, reduced CD4/CD8αα intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice

Specific pathogen-free IL-10 KO mice failed to develop inflammatory bowel disease (IBD), whereas IL-10/vitamin D receptor (VDR) double KO mice developed fulminating IBD. WT CD4 T cells inhibited experimental IBD, while VDR KO CD4 T cells failed to suppress IBD. VDR KO mice had normal numbers and fun...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yu, Sanhong, Bruce, Danny, Froicu, Monica, Weaver, Veronika, Cantorna, Margherita T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634903/
https://ncbi.nlm.nih.gov/pubmed/19095793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808700106
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