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Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies
PURPOSE: Transport of the hepatobiliary scintigraphy agent Tc-99m mebrofenin (MEB) was characterized, and simulation studies were conducted to examine the effects of altered hepatic transport on MEB pharmacokinetics in humans. METHODS: MEB transport was investigated in Xenopus laevis oocytes express...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2634848/ https://ncbi.nlm.nih.gov/pubmed/18509604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-008-9597-0 |
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