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Impact of Basolateral Mrp3 (Abcc3) and Mrp4 (Abcc4) on the Hepatobiliary Disposition of Fexofenadine in Perfused Mouse Livers
The disposition of fexofenadine, a commonly-used antihistamine drug, is governed primarily by active transport. Biliary excretion of the parent compound is the major route of systemic clearance. Previous studies demonstrated that fexofenadine hepatic uptake is mediated by organic anion transporting...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2634847/ https://ncbi.nlm.nih.gov/pubmed/18276836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.107.019273 |
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