Direct effects of doxorubicin on skeletal muscle contribute to fatigue

Chemotherapy-induced fatigue is a multidimensional symptom. Oxidative stress has been proposed as a working mechanism for anthracycline-induced cardiotoxicity. In this study, doxorubicin (DOX) was tested on skeletal muscle function. Doxorubicin induced impaired ex vivo skeletal muscle relaxation fol...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: van Norren, K, van Helvoort, A, Argilés, J M, van Tuijl, S, Arts, Karin, Gorselink, M, Laviano, A, Kegler, D, Haagsman, H P, van der Beek, E M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
Schlagworte:
Short Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634729/
https://ncbi.nlm.nih.gov/pubmed/19165199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604858
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