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Folate and colorectal cancer prevention

Anti-folate chemotherapy agents such as methotrexate and fluorouracil reduce proliferation of neoplastic cells by inhibiting DNA synthesis. Paradoxically epidemiological data suggests an inverse relationship between dietary folate intake and incidence of colorectal cancer (CRC). On the basis of this...

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Hlavní autoři: Hubner, R A, Houlston, R S
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634716/
https://ncbi.nlm.nih.gov/pubmed/19088716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604823
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