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The bZIP Targets Overlapping DNA Subsites within a Half-Site, Resulting in Increased Binding Affinities

We previously reported that the wt bZIP, a hybrid of the GCN4 basic region and C/EBP leucine zipper, not only recognizes GCN4 cognate site AP-1 (TGACTCA) but also selectively targets noncognate DNA sites, in particular the C/EBP site (TTGCGCAA). In this work, we used electrophoretic mobility shift a...

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Detalhes bibliográficos
Main Authors: Chan, I-San, Shahravan, S. Hesam, Fedorova, Anna V., Shin, Jumi A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633644/
https://ncbi.nlm.nih.gov/pubmed/18702507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800355t
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