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Induction of Angiogenesis by Heat Shock Protein 90 Mediated by Protein Kinase Akt and Endothelial Nitric Oxide Synthase

OBJECTIVE: A specific inhibitor of heat shock protein 90 (Hsp90), 17-AAG, has been shown to inhibit tumor growth through cell cycle arrest, differentiation, or apoptosis. Because angiogenesis is important for tumor growth, we hypothesize that inhibition of angiogenesis by 17-AAG may mediate some of...

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Bibliografische gegevens
Hoofdauteurs: Sun, Jianxin, Liao, James K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2004
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633590/
https://ncbi.nlm.nih.gov/pubmed/15486309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/01.ATV.0000147894.22300.4c
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