Nitric oxide and TNF-α trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice

Recombinase-activating gene-2-deficient (Rag2(−/−)) mice lacking functional lymphocytes provide a useful model of chronic inflammatory bowel disease-emulating events in human colon cancer. Infection of Rag2(−/−) mice with Helicobacter hepaticus led to accumulation of macrophages and neutrophils in t...

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Main Authors: Erdman, S. E., Rao, V. P., Poutahidis, T., Rogers, A. B., Taylor, C. L., Jackson, E. A., Ge, Z., Lee, C. W., Schauer, D. B., Wogan, G. N., Tannenbaum, S. R., Fox, J. G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633549/
https://ncbi.nlm.nih.gov/pubmed/19164562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812347106
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