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Conditional Deletion of Krüppel-Like Factor 4 Delays Downregulation of Smooth Muscle Cell Differentiation Markers but Accelerates Neointimal Formation Following Vascular Injury

Phenotypic switching of smooth muscle cells (SMCs) plays a key role in vascular proliferative diseases. We previously showed that Krüppel-like factor 4 (Klf4) suppressed SMC differentiation markers in cultured SMCs. Here, we derive mice deficient for Klf4 by conditional gene ablation and analyze the...

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Bibliografiske detaljer
Main Authors: Yoshida, Tadashi, Kaestner, Klaus H., Owens, Gary K.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633447/
https://ncbi.nlm.nih.gov/pubmed/18483411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.176974
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