Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1

Experience-dependent changes in the structure of dendritic spines may contribute to learning and memory. Encoded by three genes, the Shank family of postsynaptic scaffold proteins are abundant and enriched in the postsynaptic density (PSD) of central excitatory synapses. When expressed in cultured h...

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Detalhes bibliográficos
Main Authors: Hung, Albert Y., Futai, Kensuke, Sala, Carlo, Valtschanoff, Juli G., Ryu, Jubin, Woodworth, Mollie A., Kidd, Fleur L., Sung, Clifford C., Miyakawa, Tsuyoshi, Bear, Mark F., Weinberg, Richard J., Sheng, Morgan
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633411/
https://ncbi.nlm.nih.gov/pubmed/18272690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3032-07.2008
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