An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins

Zinc-finger proteins (ZFPs) have long been recognized for their potential to manipulate genetic information because they can be engineered to bind novel DNA targets. Individual zinc-finger domains (ZFDs) bind specific DNA triplet sequences; their apparent modularity has led some groups to propose me...

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Bibliographic Details
Main Authors: Sander, Jeffry D., Zaback, Peter, Joung, J. Keith, Voytas, Daniel F., Dobbs, Drena
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632909/
https://ncbi.nlm.nih.gov/pubmed/19056825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn962
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