Rat Urinary Bladder Carcinogenesis by Dual-Acting PPARα + γ Agonists

Despite clinical promise, dual-acting activators of PPARα and γ (here termed PPARα+γ agonists) have experienced high attrition rates in preclinical and early clinical development, due to toxicity. In some cases, discontinuation was due to carcinogenic effect in the rat urothelium, the epithelial lay...

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Detalles Bibliográficos
Autores principales: Oleksiewicz, Martin B., Southgate, Jennifer, Iversen, Lars, Egerod, Frederikke L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2008
Materias:
Review Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632771/
https://ncbi.nlm.nih.gov/pubmed/19197366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2008/103167
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