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Rat Urinary Bladder Carcinogenesis by Dual-Acting PPARα + γ Agonists
Despite clinical promise, dual-acting activators of PPARα and γ (here termed PPARα+γ agonists) have experienced high attrition rates in preclinical and early clinical development, due to toxicity. In some cases, discontinuation was due to carcinogenic effect in the rat urothelium, the epithelial lay...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Hindawi Publishing Corporation
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2632771/ https://ncbi.nlm.nih.gov/pubmed/19197366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2008/103167 |
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