Overexpression of Wild-Type Aspartokinase Increases l-Lysine Production in the Thermotolerant Methylotrophic Bacterium Bacillus methanolicus

Aspartokinase (AK) controls the carbon flow into the aspartate pathway for the biosynthesis of the amino acids l-methionine, l-threonine, l-isoleucine, and l-lysine. We report here the cloning of four genes (asd, encoding aspartate semialdehyde dehydrogenase; dapA, encoding dihydrodipicolinate synth...

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Hauptverfasser: Jakobsen, Øyvind M., Brautaset, Trygve, Degnes, Kristin F., Heggeset, Tonje M. B., Balzer, Simone, Flickinger, Michael C., Valla, Svein, Ellingsen, Trond E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Physiology and Biotechnology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632123/
https://ncbi.nlm.nih.gov/pubmed/19060158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01176-08
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