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Vip-Grafted Sterically Stabilized Phospholipid Nanomicellar 17-Allylamino-17-Demethoxy Geldanamycin: A Novel Targeted Nanomedicine for Breast Cancer
17-Allylamino-17-demethoxy geldanamycin (17-AAG), an inhibitor of heat shock protein 90 (Hsp90) function, is being developed as antitumor drug in patients with breast cancer. However, water-insolubility and hepatotoxicity limit its use. The purpose of this study was to begin to address these issues...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2631986/ https://ncbi.nlm.nih.gov/pubmed/18793708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2008.08.024 |
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