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Senescence induction; a possible cancer therapy

Cellular immortalization is a crucial step during the development of human cancer. Primary mammalian cells reach replicative exhaustion after several passages in vitro, a process called replicative senescence. During such a state of permanent growth arrest, senescent cells are refractory to physiolo...

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Detalhes bibliográficos
Main Authors: LLeonart, Matilde E, Artero-Castro, Ana, Kondoh, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631463/
https://ncbi.nlm.nih.gov/pubmed/19133111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-3
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