Bacterial Infection of Smad3/Rag2 Double-Null Mice with Transforming Growth Factor-β Dysregulation as a Model for Studying Inflammation-Associated Colon Cancer

Alterations in genes encoding transforming growth factor-β-signaling components contribute to colon cancer in humans. Similarly, mice deficient in the transforming growth factor-β signaling molecule, Smad3, develop colon cancer, but only after a bacterial trigger occurs, resulting in chronic inflamm...

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Main Authors: Maggio-Price, Lillian, Treuting, Piper, Bielefeldt-Ohmann, Helle, Seamons, Audrey, Drivdahl, Rolf, Zeng, Weiping, Lai, LapHin, Huycke, Mark, Phelps, Susan, Brabb, Thea, Iritani, Brian M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2009
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631344/
https://ncbi.nlm.nih.gov/pubmed/19119184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080485
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