Failure of Pelvic Organ Support in Mice Deficient In Fibulin-3

Fibulin-5 is crucial for normal elastic fiber synthesis in the vaginal wall; more than 90% of fibulin-5-knockout mice develop pelvic organ prolapse by 20 weeks of age. In contrast, fibulin-1 and -2 deficiencies do not result in similar pathologies, and fibulin-4-knockout mice die shortly after birth...

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Bibliographic Details
Main Authors: Rahn, David D., Acevedo, Jesús F., Roshanravan, Shayzreen, Keller, Patrick W., Davis, Elaine C., Marmorstein, Lihua Y., Word, R. Ann
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631333/
https://ncbi.nlm.nih.gov/pubmed/19095964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080212
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