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Failure of Pelvic Organ Support in Mice Deficient In Fibulin-3
Fibulin-5 is crucial for normal elastic fiber synthesis in the vaginal wall; more than 90% of fibulin-5-knockout mice develop pelvic organ prolapse by 20 weeks of age. In contrast, fibulin-1 and -2 deficiencies do not result in similar pathologies, and fibulin-4-knockout mice die shortly after birth...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Investigative Pathology
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2631333/ https://ncbi.nlm.nih.gov/pubmed/19095964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080212 |
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