Mouse Pancreatic Islets Are Resistant to Indoleamine 2,3 Dioxygenase-Induced General Control Nonderepressible-2 Kinase Stress Pathway and Maintain Normal Viability and Function

Islet transplantation is a promising treatment for diabetes. However, it faces several challenges including requirement of systemic immunosuppression. Indoleamine 2,3-dioxygenase (IDO), a tryptophan degrading enzyme, is a potent immunomodulatory factor. Local expression of IDO in bystander fibroblas...

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Autors principals: Jalili, Reza B., Forouzandeh, Farshad, Moeenrezakhanlou, Alireza, Rayat, Gina R., Rajotte, Ray V., Uludag, Hasan, Ghahary, Aziz
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2009
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631332/
https://ncbi.nlm.nih.gov/pubmed/19074614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080539
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