Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin

Aged human skin is fragile because of fragmentation and loss of type I collagen fibrils, which confer strength and resiliency. We report here that dermal fibroblasts express increased levels of collagen-degrading matrix metalloproteinases-1 (MMP-1) in aged (>80 years old) compared with young (21...

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Detalhes bibliográficos
Main Authors: Fisher, Gary J., Quan, Taihao, Purohit, Trupta, Shao, Yuan, Cho, Moon Kyun, He, Tianyuan, Varani, James, Kang, Sewon, Voorhees, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631323/
https://ncbi.nlm.nih.gov/pubmed/19116368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080599
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