Transcriptional Regulation of Urokinase-type Plasminogen Activator Receptor by Hypoxia-Inducible Factor 1 Is Crucial for Invasion of Pancreatic and Liver Cancer

Angioinvasion is critical for metastasis with urokinase-type plasminogen activator receptor (uPAR) and tumor hypoxia-activated hypoxia-inducible factor 1 (HIF-1) as key players. Transcriptional control of uPAR expression by HIF has never been reported. The aim of the present study, therefore, was to...

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Autores principales: Büchler, Peter, Reber, Howard A, Tomlinson, James S, Hankinson, Oliver, Kallifatidis, Georgis, Friess, Helmut, Herr, Ingrid, Hines, Oscar J
Formato: Artigo
Lenguaje:Inglês
Publicado: Neoplasia Press Inc. 2009
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631144/
https://ncbi.nlm.nih.gov/pubmed/19177204
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