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Structural analysis of site-directed mutants of cellular retinoic acid-binding protein II addresses the relationship between structural integrity and ligand binding

The structural integrity of cellular retinoic acid-binding protein II (CRABPII) has been investigated using the crystal structures of CRABPII mutants. The overall fold was well maintained by these CRABPII mutants, each of which carried multiple different mutations. A water-mediated network is found...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Vaezeslami, Soheila, Jia, Xiaofei, Vasileiou, Chrysoula, Borhan, Babak, Geiger, James H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: International Union of Crystallography 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631107/
https://ncbi.nlm.nih.gov/pubmed/19018099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444908032216
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