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Preclinical Characterization of a (S)-N-(4-Cyano-3-Trifluoromethyl-Phenyl)-3-(3-Fluoro, 4-Chlorophenoxy)-2-Hydroxy-2-Methyl-Propanamide: A Selective Androgen Receptor Modulator for Hormonal Male Contraception

The pharmacologic effects of (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide (S-23) were characterized in male rats as an animal model of hormonal male contraception. S-23 showed high binding affinity (inhibitory constant = 1.7 ± 0.2 nm) and was...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Jones, Amanda, Chen, Jiyun, Hwang, Dong Jin, Miller, Duane D., Dalton, James T.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The Endocrine Society 2009
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630904/
https://ncbi.nlm.nih.gov/pubmed/18772237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0674
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