Hypoxia and Leucine Deprivation Induce Human Insulin-Like Growth Factor Binding Protein-1 Hyperphosphorylation and Increase Its Biological Activity

Fetal growth restriction is often caused by uteroplacental insufficiency that leads to fetal hypoxia and nutrient deprivation. Elevated IGF binding protein (IGFBP)-1 expression associated with fetal growth restriction has been documented. In this study we tested the hypothesis that hypoxia and nutri...

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Main Authors: Seferovic, Maxim D., Ali, Rashad, Kamei, Hiroyasu, Liu, Suya, Khosravi, Javad M., Nazarian, Steven, Han, Victor K. M., Duan, Cunming, Gupta, Madhulika B.
Format: Artigo
Language:Inglês
Published: The Endocrine Society 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630895/
https://ncbi.nlm.nih.gov/pubmed/18772238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0657
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