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Embryonic Stem Cell Specific MicroRNAs Regulate the G1/S Transition and Promote Rapid Proliferation

Dgcr8 knockout embryonic stem (ES) cells lack microprocessor activity and hence all canonical microRNAs (miRNAs). These cells proliferate slowly and accumulate in G1 phase of the cell cycle1. Here, by screening a comprehensive library of individual miRNAs in the background of the Dgcr8 knockout ES c...

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Main Authors: Wang, Yangming, Baskerville, Scott, Shenoy, Archana, Babiarz, Joshua E, Baehner, Lauren, Blelloch, Robert
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630798/
https://ncbi.nlm.nih.gov/pubmed/18978791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.250
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