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Mutant Telomeric Repeats in Yeast Can Disrupt the Negative Regulation of Recombination-Mediated Telomere Maintenance and Create an Alternative Lengthening of Telomeres-Like Phenotype

Some human cancers maintain telomeres using alternative lengthening of telomeres (ALT), a process thought to be due to recombination. In Kluyveromyces lactis mutants lacking telomerase, recombinational telomere elongation (RTE) is induced at short telomeres but is suppressed once telomeres are moder...

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Detalles Bibliográficos
Main Authors: Bechard, Laura H., Butuner, Bilge D., Peterson, George J., McRae, Will, Topcu, Zeki, McEachern, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630680/
https://ncbi.nlm.nih.gov/pubmed/19029249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00423-08
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