Giardia, Entamoeba, and Trichomonas Enzymes Activate Metronidazole (Nitroreductases) and Inactivate Metronidazole (Nitroimidazole Reductases)

Infections with Giardia lamblia, Entamoeba histolytica, and Trichomonas vaginalis, which cause diarrhea, dysentery, and vaginitis, respectively, are each treated with metronidazole. Here we show that Giardia, Entamoeba, and Trichomonas have oxygen-insensitive nitroreductase (ntr) genes which are hom...

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Main Authors: Pal, Dibyarupa, Banerjee, Sulagna, Cui, Jike, Schwartz, Aaron, Ghosh, Sudip K., Samuelson, John
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Assuntos:
Mechanisms of Action: Physiological Effects
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630645/
https://ncbi.nlm.nih.gov/pubmed/19015349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00909-08
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