Giardia, Entamoeba, and Trichomonas Enzymes Activate Metronidazole (Nitroreductases) and Inactivate Metronidazole (Nitroimidazole Reductases)

Infections with Giardia lamblia, Entamoeba histolytica, and Trichomonas vaginalis, which cause diarrhea, dysentery, and vaginitis, respectively, are each treated with metronidazole. Here we show that Giardia, Entamoeba, and Trichomonas have oxygen-insensitive nitroreductase (ntr) genes which are hom...

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Auteurs principaux: Pal, Dibyarupa, Banerjee, Sulagna, Cui, Jike, Schwartz, Aaron, Ghosh, Sudip K., Samuelson, John
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2009
Sujets:
Mechanisms of Action: Physiological Effects
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630645/
https://ncbi.nlm.nih.gov/pubmed/19015349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00909-08
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