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In Vitro Activity of LK-157, a Novel Tricyclic Carbapenem As Broad-Spectrum β-Lactamase Inhibitor

LK-157 is a novel tricyclic carbapenem with potent activity against class A and class C β-lactamases. When tested against the purified TEM-1 and SHV-1 enzymes, LK-157 exhibited 50% inhibitory concentrations (IC(50)s) in the ranges of the clavulanic acid and tazobactam IC(50)s (55 nM and 151 nM, resp...

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Main Authors: Paukner, Susanne, Hesse, Lars, Preželj, Andrej, Šolmajer, Tomaž, Urleb, Uroš
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630636/
https://ncbi.nlm.nih.gov/pubmed/19075067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00085-08
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