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Inhibition of Inositol Phosphorylceramide Synthase by the Cyclic Peptide Aureobasidin A
By using a detergent-washed membrane preparation, the interaction of the fungal natural product inhibitor aureobasidin A (AbA) with inositol phosphorylceramide synthase (IPC synthase) was studied by kinetic analysis of wild-type and mutant enzyme-catalyzed reactions. AbA inhibited the wild-type enzy...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2630602/ https://ncbi.nlm.nih.gov/pubmed/19047657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00633-08 |
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